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KMID : 0043319850080020059
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Archives of Pharmacal Research
1985 Volume.8 No. 2 p.59 ~ p.65
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Studies on the Anti-inflammatory Activity of Aralia continentalis (III)
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Han BH
Woo ER/Park MH/Han YN
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Abstract
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Besides (-)-pimara-8(14), 15-dien-19-oic acid [I] which had already been isolated as an active anti-inflammtory principle of Aralia continentalis, (-)-kaur-16-en-19-oic acid [II] was separated as another active component of the plant, by tracing albumin stabilizing activity. IC50 of [II] for the protein stabilizing activity was 0.026mg/3ml, when those of [I] and phenylbutazone were 0.032 and 0.32 mg/3 ml, respectively. Being investigated employing carrageenin-induced edema test in rat hind paw, the anti-inflammatory activity of [II] administered s.c. was slightly lower than that of phenylbutazone, whereas the activity of [II] administered p.o. was three times greater than that of phenylbutazone. These results of [II] were contrary to those of [I] in the aspect of administration routes.
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